Antiaggregants

 

1- Indications:

A- Clopidogrel (Plavix):

* Severe arterial disease of lower members

* Ischemic stroke more than 7 days

* Unstable angina, myocardial

B- Persantine:

* Stroke Prevention

* Adjuvant treatment of coronary artery disease

C- Abciximab:

* Myocardial infarction

* Acute coronary syndrome with non-Q wave infarction

* Coronary Angioplasty

– Clopidogrel (Plavix®) -> ADP antagonist); ticlopidine (Ticlid)

– Dipyridamole (Persantine®) -> inhibiting the reuptake of adenosine (secondary effects: angina with coronary steal; vasodilation; bile calculated).

– GP IIb receptor antagonists / IIIb (Integrelin®) and Abciximab

Blood paroie

Blood paroie

2- Heparins:

A- information:

– Venous Thrombosis and Pulmonary Embolism

– Myocardial infarction in the acute phase

– Acute arterial obliteration members

– Original embolic stroke

– Substitution of AVK during pregnancy

B- Contraindications:

a- Absolute:

– Pericarditis; endocarditis; aortic dissection

– Hemorrhagic stroke

– Peptic ulcer recent

– Diabetic retinopathy

– Major hemorrhagic syndrome

– History of thrombocytopenia with heparin

b- Relatives:

– Liver failure

– Renal failure

– Honeymoon

– Severe hypertension

3- Fibrinolytics:

A- information:

– Myocardial infarction in the acute phase (before 12 hours)

– Massive pulmonary embolism

– Acute ischemia of the lower limbs

B- Absolute contraindications:

– AVC <2 months; intracranial pathology (neoplasia …)

– History of hemorrhagic stroke

– Pericarditis; endocarditis, and uncontrolled hypertension; A dissection

– Proliferative retinopathy; recent eye surgery

– Surgery <10 days (cerebro-spinal <2 months)

– Peptic ulcer

– Recent puncture (<48 hours) of an artery or of a compression member without possibility

– Severe hepatocellular insufficiency

– Other: malignancy; disorder of blood dyscrasias;

C- Relative contraindications:

– Fairly recent surgery (15 days)

– Recent puncture (48h) in a compressible territory

– History of gastrointestinal bleeding or PUD

– Strong external cardiac massage

– The valve prosthesis Dacron

– Hepatic Dysfunction

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