Glycosylated Hemoglobin or Glycated

 

Indications:

The assay is useful in monitoring the effectiveness of diabetes care.

Principle:

hemoglobin HbA1c is a subfraction of HbA1c, which reacts with glucose.

The value found in the blood, in proportion to the average plasma glucose concentration, therefore, is a good reflection of the latter.

Glycosylated hemoglobin or glycatedTechnique:

Sample of 5 mL of venous blood in EDTA (ethylene diamino tetraacetic acid) or hepatitis.

Determination by high liquid chromatography, chromatography on ion exchange resin or by enzyme immunoassay.

Results:

They are based on laboratory methods and standards;

– HbA1a + HbA1b + HbA1c: 6 to 8% of the total hemoglobin;

– Only HbA1c: 4 to 6%.

In a properly balanced diabetic, HbA1c should be close to 6%; unbalanced, it is around 8 to 12%.

An increase of 0.3 g / L glycerin gives a 1% increase in glycated hemoglobin.

Cost:

B60.

Practical advice:

The lifetime of decreased red blood cells underestimate the value of glycated hemoglobin, which is however overestimated in renal failure.

This exam is to practice every three months for NIDDM (type II diabetes non-insulin dependent), unless it is unbalanced.

It can in no case be used to screen for diabetes.

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