Synthesized by the liver, the serum albumin used as carrier for many ligand and plays a crucial role in maintaining the oncotic pressure of plasma. This is by far the most abundant protein in serum (60% serum protein).
• Diagnosis of liver failure at a hepatobiliary disease.
• Confirmation of the diagnosis of nephrotic syndrome before edema with proteinuria.
• Review malabsorption discovered during chronic diarrhea.
Blood collected on dry or heparinized tube.
35 to 50 g / L
In children under 1 year:
35 to 40 g / L
The Hyperalbuminemia is indicative of an extracellular dehydration.
Hypoalbuminemia shows either a summary of failure or urinary or digestive protein-losing.
Hypoalbuminaemia may be due to malnutrition.
It is mainly caused by liver failure which hypoalbuminemia, with the lowering of the factors of the prothrombin complex, the best sign.
Urinary albumin losses realized nephrotic syndrome, where albumin> 30 g / L is associated with proteinuria> 3 g / day (50 mg / kg / day in children) (see Proteinuria).
Digestive albumin losses are due to malabsorption.
The hypoalbubinémie is particularly marked in the malabsorption of chronic enteropathy – celiac disease, Whipple’s disease, short bowel, intestinal lymphoma – usually discovered during the assessment of chronic diarrhea.
Two malabsorption to know:
Celiac disease results in adults by diarrhea, abdominal pain and in 20% of cases, with hypoalbubinémie malabsorption, anemia, folate deficiency … Finding transglutaminase (anti-tTG-IgA) and endomysial contributes to the diagnosis.
Intestinal lymphangiectasis strikes children and young adults. It is revealed by edema and diarrhea. The hypoalbubinémie is accompanied by a decrease of immunoglobulins, transferrin and ceruloplasmin.