– Definition: characterized by the increase in the size (above normal) distal airspaces beyond the terminal bronchiole, or by expansion or by rupture of the alveolar walls.
– Two types: diffuse emphysema panacinar and centrilobular emphysema.
– Emphysema diffuse panacinar: destruction of alveolar walls; conjunctiva and parallel weft of the capillary network;expansion of all the acini; predominantly to the database; generally primitive.
– The centrilobular emphysema predominant expansion of the respiratory bronchioles causing the acinus (terminal bronchioles). inflammation of the membranous bronchi and bronchioles; no destruction of the capillary networks;progressive form of chronic pulmonary disease.
– The emphysema located adjacent to parenchymal lesions and are paracicatriciels. It is not by definition of COPD.
Panacinar emphysema (Type A):
– Cause: congenital deficiency of protease inhibitors (alpha1-antitripsine)
– There is no effect of shunt and gas resting blood have long kept; PAH and CPC are late.
– The total area of gas exchange is reduced => decrease in OBT (transfer CO) and arterial desaturation during exercise.
– The lesions start and dominate the bases.
– Clinical picture -> Pink Puffler (winded pink) with exercise dyspnea;absence of cyanosis and clubbing; no rattling.
– Are typically absent (at Rx) signs of airway inflammation and signs of PAH and CPC (drop in heart).
– Troubles obstructive ventilatory (FEV down) -> early signs.
– No shunt effect with no indication of almitrine
Centrilobular emphysema (Type B):
– Causes: always associated with severe COPD; stage CKD; tobacco is likely to cause destructive lesions of the parenchyma.
– The lesions develop in the central part of the acinus, respecting alveolar vessels. Predominate in the upper lobes
– The shunt has a major effect with hypoxemia and hypercapnia often rest development of PAH and a CPC.
– An array of blue Blotter (blue puffy) about chronic bronchitis, overweight and cyanotic, signs of right ventricular failure often present.
– Hypoxemia and hypercapnia at rest with polycythemia
– Continuous oxygen therapy significantly improves survival and patient case comfort and reduces the frequency of complications.