Tag: Hemoglobin
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Glycosylated Hemoglobin or Glycated
Indications: The assay is useful in monitoring the effectiveness of diabetes care. Principle: hemoglobin HbA1c is a subfraction of HbA1c, which reacts with glucose. The value found in the blood, in proportion to the average plasma glucose concentration, therefore, is a good reflection of the latter. Technique: Sample of 5 mL of venous blood in…
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Hemoglobin Electrophoresis
Indications: The examination is useful when suspected hemolytic anemia or haematological disease associated with the patient’s geographic origin, namely Africa, specifically the southern Sahara. Principle: The majority of abnormal hemoglobins have a different electric charge from normal: the amino acids of the globin located outside are hydrophilic effect and electrically charged. By subjecting the hemoglobin…
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Thalassemia, sickle cell disease
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Genetic disorders of hemoglobin are classified into two main categories: thalassemia and hemoglobinopathies whose most common form is sickle cell anemia. Structure and organization of hemoglobin genes: Chromosome 16 carries two α-globinedénommés genes respectively, from 5 ‘to 3’, a2 globin and a1-globin.These genes are composed of 3 exons and 2 introns.Each of the 4-α genes…
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