Multiple endocrine neoplasia 1:
* SYNDROME Wermer:
Multiple endocrine neoplasia type I:
– Hyperparathyroidism 90 to 100%
– Violation of the endocrine pancreas (90%): Zollinger-Ellison syndrome (gastrinoma) insulinoma; glucanome;vipoma (Verner and Morrison syndrome)
– Involvement of the anterior pituitary (40%): GH adenoma; prolactinoma
– Carcinoid tumor (5%)
* SPPEL SYNDROME (NMS TYPE 2a):
– Medullary Thyroid Cancer
– Hyperparathyroidism
– Pheochromocytoma
2- Polyendocrinopathy autoimmune:
* Whitaker syndrome (type I): mucocutaneous candidiasis; hypoparathyroidism; adrenal insufficiency
* Schmidt syndrome (type II): adrenal insufficiency and autoimmune thyroid disease
